Francesca Citron

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Articles

WRAD core perturbation impairs DNA replication fidelity promoting immunoediting in pancreatic cancer

Oct 24, 2024 | biorxiv.org | Francesca Citron |I-Lin Ho |Chiara Balestrieri |Zhaoliang Liu

AbstractIt is unclear how cells counteract the potentially harmful effects of uncoordinated DNA replication in the context of oncogenic stress. Here, we identify the WRAD (WDR5/RBBP5/ASH2L/DPY30) core as a modulator of DNA replication in pancreatic ductal adenocarcinoma (PDAC) models.

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