Fred Machyo Okuku

Nov 26, 2024 | biorxiv.org | Catherine Byrne |Fred Machyo Okuku |Janet Nankoma |Innocent Mutyaba

AbstractHuman herpesvirus-8 (HHV-8) is a gamma herpesvirus linked to the development of Kaposi sarcoma (KS). KS is more common in persons living with HIV (PLWH), but endemic KS in HIV-negative individuals is also common in sub-Saharan Africa. HHV-8 shedding occurs in the oral mucosa and is likely responsible for transmission. The mechanistic drivers of different HHV-8 shedding patterns in infected individuals are unknown.