Freddy Frost

Aug 6, 2024 | onlinelibrary.wiley.com | José Miguel Rivera-Caravaca |Liverpool John Moores |Liverpool Heart |Freddy Frost

1 INTRODUCTION Since the initial phases of the coronavirus disease 2019 (COVID-19) pandemic, patients positive for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) were identified as having a prothrombotic profile and therefore a higher risk of thrombosis.1, 2 For this reason, different antithrombotic agents, including oral anticoagulation (OAC), emerged as therapeutic options for preventing and treating COVID-19-associated thrombotic disease.3 Other drugs with pleiotropic actions...

Jun 27, 2024 | bmjopenrespres.bmj.com | Patrick Bradley |Freddy Frost |Kukatharmini Tharmaratnam |Daniel G. Wootton

DiscussionWe analysed the accuracy with which admission CURB-65, NEWS2 and qSOFA scores predict ICU admission, early in hospital mortality and all-cause mortality within 30 days of hospital admission in the context of COVID-19. In general, calibration was poor as all three scores underestimated the risk of adverse outcomes. CURB-65 and qSOFA both performed poorly in comparison to their respective standard applications, suggesting their utility is limited in COVID-19.