Articles

  • 2 weeks ago | ajmc.com | Maggie L. Shaw |Frederick Locke

    The phase 1 ALPHA (NCT03939026) and phase 1/2 ALPHA2 (NCT04416984) trials are investigating cemacabtagene ansegedleucel (cema-cel), an allogeneic chimeric antigen receptor (CAR) T-cell therapy in relapsed/refractory large B-cell lymphoma. Findings from these 2 trials comprise the foundation for the phase 2 ALPHA3 (NCT06500273) trial, which is evaluating first-line consolidation treatment with cema-cel in patients with a low disease burden.

  • 1 month ago | ajmc.com | Maggie L. Shaw |Frederick Locke

    Cemacabtagene ansegedleucel (cema-cel; Allogene Therapeutics) is an allogeneic chimeric antigen receptor (CAR) T-cell therapy currently being investigated for relapsed/refractory large B-cell lymphoma, a type of non-Hodgkin lymphoma, in the ALPHA (NCT03939026) and ALPHA2 (NCT04416984) clinical trials. Lead investigator Frederick L.

  • 2 months ago | ajmc.com | Maggie L. Shaw |Frederick Locke

    The investigational allogeneic chimeric antigen receptor (CAR) T-cell therapy cemacabtagene ansegedleucel (cema-cel; Allogene Therapeutics) is being evaluated in the ALPHA (NCT03939026) and ALPHA2 (NCT04416984) trials for relapsed/refractory large B-cell lymphoma, a type of non-Hodgkin lymphoma, and in the ALPHA3 trial (NCT06500273) in patients with a low disease burden who have received cema-cel as consolidation treatment in the first line. Continuing a discussion with Frederick L.

  • Mar 7, 2025 | ajmc.com | Maggie L. Shaw |Frederick Locke

    In part 2 of this interview with Frederick L. Locke, MD, lead investigator on the phase 1 ALPHA (NCT03939026) and ALPHA2 (NCT04416984) trials of allogeneic chimeric antigen receptor T-cell therapy (CAR T) in relapsed/refractory large B-cell lymphoma (LBCL), explains why this hematologic cancer is such an attractive target for CAR T, specifically allogeneic, which uses healthy donor cells.

  • Feb 24, 2025 | ajmc.com | Maggie L. Shaw |Frederick Locke

    Cemacabtagene ansegedleucel (cema-cel; Allogene Therapeutics) has robust data that reinforce its durability, effectiveness, and safety as an allogeneic chimeric antigen receptor (CAR) T-cell therapy for patients who have relapsed/refractory large B-cell lymphoma, a type of non-Hodgkin lymphoma.

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