Frederick W. Alt

Jun 14, 2024 | nature.com | Ivy Phung |Olivia K. Swanson |Chang-Chun D. Lee |Ester Marina-Zárate |Gabriel Ozorowski |Kimmo Rantalainen | +28 more

Correction to: Nature Immunology https://doi.org/10.1038/s41590-024-01833-w, published online 30 May 2024In the version of the article initially published, Steven Schultze’s surname appeared incorrectly (as Schulze) and has now been amended in the HTML and PDF versions of the article.

May 30, 2024 | nature.com | Ivy Phung |Olivia K. Swanson |Chang-Chun D. Lee |Ester Marina-Zárate |Gabriel Ozorowski |Kimmo Rantalainen | +28 more

AbstractA key barrier to the development of vaccines that induce broadly neutralizing antibodies (bnAbs) against human immunodeficiency virus (HIV) and other viruses of high antigenic diversity is the design of priming immunogens that induce rare bnAb-precursor B cells.

Jun 20, 2023 | pnas.org | Frederick W. Alt |Adam Yongxin |Anuj K. Shah |Jiaying Zhao

Y. Zhang, X. Zhang, H.-Q. Dai, H. Hu, F. W. Alt, The role of chromatin loop extrusion in antibody diversification. Nat. Rev. Immunol. 9, 1–17 (2022). C. Liu, Y. Zhang, C. C. Liu, D. G. Schatz, Structural insights into the evolution of the RAG recombinase. Nat. Rev. Immunol. 22, 353–370 (2022). F. W. Alt, Y. Zhang, F.-L. Meng, C. Guo, B. Schwer, Mechanisms of programmed DNA lesions and genomic instability in the immune system. Cell 152, 417–429 (2013). Y.