Fredrik Piehl

Oct 3, 2024 | nature.com | Henrik Zetterberg |Per Svenningsson |Fredrik Piehl

AbstractTraumatic brain injury (TBI) is a leading cause of long-term disability across the world. Evidence for the usefulness of imaging and fluid biomarkers to predict outcomes and screen for the need to monitor complications in the acute stage is steadily increasing. Still, many people experience symptoms such as fatigue and cognitive and motor dysfunction in the chronic phase of TBI, where objective assessments for brain injury are lacking.

Apr 12, 2024 | nature.com | Michael Khalil |Sylvain Lehmann |Markus Otto |Fredrik Piehl |Stefan Bittner |Maria Pia Sormani | +8 more

AbstractNeurofilament proteins have been validated as specific body fluid biomarkers of neuro-axonal injury. The advent of highly sensitive analytical platforms that enable reliable quantification of neurofilaments in blood samples and simplify longitudinal follow-up has paved the way for the development of neurofilaments as a biomarker in clinical practice.

Apr 13, 2023 | jnnp.bmj.com | Kelsi A Smith |Fredrik Piehl |Tomas Olsson |Lars Alfredsson

DiscussionTo the best of our knowledge, this is the first study consisting of a real-world MS population followed for a period of 10 years capturing routine clinical practice in treating spasticity among both incident and prevalent patients with MS. Baclofen remains the first-line option for managing spasticity in MS, and patterns of initiation and discontinuation described in this study are relevant to inform future clinical practice.