Fs Creation

May 20, 2024 | academic.oup.com | Fs Creation

We investigate the molecular mechanism of acetonitrile-induced structural changes in a cutinase-like enzyme in a giant coordination cage using molecular dynamics (MD) simulations. As the acetonitrile content within the cage increases, significant conformational changes of the caged protein occur due to acetonitrile binding to the specific sites, in line with protein denaturation events observed in previous nuclear magnetic resonance (NMR) studies.

Mar 25, 2024 | chemistry-europe.onlinelibrary.wiley.com | Youngcheol Jung |Fs Creation |Takaaki Mitsuhashi |Takashi Kikuchi

Terpene synthases, crucial enzymes in terpenoid biosynthesis, have been extensively studied across various organisms, including plants, bacteria, fungi, non–seed land plants, red algae, amoebae, insects, corals, and sponges.1-9 Recently, we characterized a viral class I terpene synthase, OILTS,10 discovered through genome mining of a giant virus Orpheovirus IHUMI–LCC2.11 OILTS, phylogenetically isolated from terpene synthases from cellular organisms, exhibits a compact and simple structure,10...

Aug 1, 2023 | onlinelibrary.wiley.com | Gavin Tay |Toshiaki Wayama |Hiroki Takezawa |Fs Creation

Graphical Abstract Natural Products. The X-ray crystallographic analysis of a labile dehydrosecodine-type intermediate was achieved by designing a functionally modulated analogue, enabling its inclusion within a self-assembled coordination cage, as reported by Hiroki Takezawa, Sota Sato, Makoto Fujita, Hiroki Oguri et al. in their Communication (e202305122).