Fugang Liu

Sep 4, 2024 | onlinelibrary.wiley.com | Fugang Liu |Jiaqing Liu |Yang Luo |Siyi Wu

1 Introduction Systemic aging is a complex, progressive phenomenon marked by a cascade of continuous multi-level deteriorations within the organism.[1] During aging, cells may undergo irreversible cell cycle arrest known as cellular senescence when exposed to specific acute stressors, such as metabolism dysregulation, direct DNA damage, oxidative stress, and telomere dysfunction.[2] Senescent cells accumulate in various tissues during aging and contribute to the systemic aging process through...