Gabriel Desrosiers-Gregoire

Aug 6, 2024 | nature.com | Gabriel Desrosiers-Gregoire |Gabriel A. Devenyi

AbstractFunctional magnetic resonance imaging in rodents holds great potential for advancing our understanding of brain networks. Unlike the human community, there remains no standardized resource in rodents for image processing, analysis and quality control, posing significant reproducibility limitations.

Jan 2, 2024 | nature.com | Hadi Vafaii |Francesca Mandino |Gabriel Desrosiers-Gregoire |David H. O’Connor |Xinxin Ge |Peter Herman | +3 more

AbstractLarge-scale functional networks have been characterized in both rodent and human brains, typically by analyzing fMRI-BOLD signals. However, the relationship between fMRI-BOLD and underlying neural activity is complex and incompletely understood, which poses challenges to interpreting network organization obtained using this technique. Additionally, most work has assumed a disjoint functional network organization (i.e., brain regions belong to one and only one network).

Dec 16, 2023 | biorxiv.org | Francesca Mandino |Xilin Shen |Gabriel Desrosiers-Gregoire |David O'Connor

AbstractAmyloid accumulation in Alzheimer's disease (AD) is associated with synaptic damage and altered connectivity in brain networks. While measures of amyloid accumulation and biochemical changes in mouse models have utility for translational studies of certain therapeutics, preclinical analysis of altered brain connectivity using clinically relevant fMRI measures has not been well developed for agents intended to improve neural networks.