Gaurav Thareja

Aug 19, 2024 | nature.com | Anna Halama |Shaza B. Zaghlool |Gaurav Thareja |Wadha Al Muftah |Sabine Ameling |Maja Pucic Baković | +8 more

AbstractIn-depth multiomic phenotyping provides molecular insights into complex physiological processes and their pathologies. Here, we report on integrating 18 diverse deep molecular phenotyping (omics-) technologies applied to urine, blood, and saliva samples from 391 participants of the multiethnic diabetes Qatar Metabolomics Study of Diabetes (QMDiab).

Feb 2, 2024 | nature.com | Karsten Suhre |Anna Halama |Gaurav Thareja

AbstractProteogenomics studies generate hypotheses on protein function and provide genetic evidence for drug target prioritization. Most previous work has been conducted using affinity-based proteomics approaches. These technologies face challenges, such as uncertainty regarding target identity, non-specific binding, and handling of variants that affect epitope affinity binding. Mass spectrometry-based proteomics can overcome some of these challenges.