Gautam Mereddy

Jul 13, 2024 | biorxiv.org | Barry Li |Shivani Srivastava |Mustafa Shaikh |Gautam Mereddy

AbstractAntimicrobial resistance (AMR) is a global health crisis and there is an urgent need to better understand AMR mechanisms. Antibiotic treatment alters several aspects of bacterial physiology, including increased ATP utilization, carbon metabolism, and reactive oxygen species (ROS) formation. However, how the "bioenergetic stress" induced by increased ATP utilization affects treatment outcomes is unknown.