Gautam Panda

Oct 23, 2023 | pubs.rsc.org | Indranil Chatterjee |Deblina Roy |Gautam Panda

A Scalable and Eco-friendly Total Synthesis of Poly (ADP-Ribose) Polymerase Inhibitor Olaparib A scalable toal synthesis of a potent poly (ADP-ribose) polymerase (PARP) enzyme inhibitor Olaparib (Lynparza), approved by U.S. FDA and EMA for ovarian cancer, is disclosed. The process is operationally simple, highly atom economical and environmentally benign as compared to the existing literature route to the olaparib.