Genentech Research

Apr 2, 2024 | biorxiv.org | Hanchen Wang |Jure Leskovec |Aviv Regev |Genentech Research

AbstractAlthough biological studies increasingly rely on embeddings of single cell profiles, the quality of these embeddings can be challenging to assess. Such evaluations are especially important for avoiding mis- leading biological interpretations, assessing the accuracy of integration methods, and establishing the zero-shot capabilities of foundational models. Here, we posit that current evaluation metrics can be highly misleading.