Georg Greiner

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BRD4 degraders may effectively counteract therapeutic resistance of leukemic stem cells in AML and ALL

Jun 2, 2024 | onlinelibrary.wiley.com | Karin Bauer |Alexander W. Hauswirth |Karoline V. Gleixner |Georg Greiner

1 INTRODUCTION Acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) are life-threatening stem cell malignancies characterized by an uncontrolled expansion and accumulation of leukemic blast cells in diverse hematopoietic organs, including the bone marrow (BM) and peripheral blood (PB).1-5 In ALL, the spleen and lymph nodes are also affected frequently.
BRD4 degraders may effectively counteract therapeutic resistance of leukemic stem cells in AML and ALL

Jun 2, 2024 | onlinelibrary.wiley.com | Karin Bauer |Alexander W. Hauswirth |Karoline V. Gleixner |Georg Greiner

1 INTRODUCTION Acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) are life-threatening stem cell malignancies characterized by an uncontrolled expansion and accumulation of leukemic blast cells in diverse hematopoietic organs, including the bone marrow (BM) and peripheral blood (PB).1-5 In ALL, the spleen and lymph nodes are also affected frequently.

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