Georg-Nikolaus Franke

Dec 4, 2024 | nature.com | Sarah Flossdorf |Sandra Sauer |Hartmut Goldschmidt |Monika Engelhardt |Robert Zeiser |Vladan Vucinic | +5 more

AbstractIdentifying patients who may benefit from autologous stem cell transplantation (ASCT) in newly diagnosed multiple myeloma is crucial, especially in the era of effective induction and consolidation strategies. We analyzed data from 12763 patients enrolled in the German Registry for Hematopoietic Stem Cell Transplantation and Cell Therapy (DRST), distinguishing those who underwent single (n = 8736) or tandem ASCT (n = 4027) from 1998 to 2021.

Mar 28, 2024 | nature.com | Annamaria Brioli |Tomasz Sacha |Philipp Ernst |Fausto Castagnetti |Klaus Hirschbühl |Helena Podgornik | +9 more

AbstractBlast phase (BP) of chronic myeloid leukemia (CML) still represents an unmet clinical need with a dismal prognosis. Due to the rarity of the condition and the heterogeneity of the biology and clinical presentation, prospective trials and concise treatment recommendations are lacking.

Oct 25, 2023 | nature.com | Klaus H. Metzeler |Georg-Nikolaus Franke |Vladan Vucinic |Uwe Platzbecker

To the Editor:Some of the gene mutations detected during the development of myeloid neoplasm are also frequently found in elderly individuals without diagnosed hematologic malignancy and here referred to as clonal hematopoiesis (CH) of indeterminate potential (CHIP) [1]. CHIP associates with an elevated risk of developing a myeloid neoplasm [1], as compared to non-CHIP conductors [1].

Sep 2, 2023 | nature.com | Arnon Nagler |Nicolaus Kröger |Georg-Nikolaus Franke |Gerard Socie |Johannes Schetelig |Fabio Ciceri

AbstractWe compared outcomes, of 1609 patients with secondary acute myeloid leukemia (sAML) undergoing allogeneic transplantation (HSCT) in first complete remission (CR1) from matched unrelated donors (MUD) from 2010 to 2021, receiving or not receiving anti-thymocyte globulin (ATG) (ATG-1308, no ATG-301). Median age was 60.9 (range, 18.5–77.8) and 61.1 (range, 21.8–75.7) years, (p = 0.3).