George Chenaux

Oct 17, 2023 | biorxiv.org | Ahlem Assali |George Chenaux |Jennifer Cho |Stefano Berto

AbstractEphB1 is required for proper guidance of cortical axon projections during brain development, but how EphB1 regulates this process remains unclear. We show here that EphB1 conditional knockout (cKO) in GABAergic cells (Vgat-Cre or Dlx1/2-Cre), but not in cortical excitatory neurons (Emx1-Cre), reproduced the cortical axon guidance defects observed in global EphB1 KO mice.