George J. Augustine

Nov 29, 2024 | mdpi.com | Martin Graf |George J. Augustine |Kelly Lin

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Sep 26, 2023 | nature.com | Hao Zhang |George J. Augustine

AbstractSocial recognition memory (SRM) is a key determinant of social interactions. While the cerebellum emerges as an important region for social behavior, how cerebellar activity affects social functions remains unclear. We selectively increased the excitability of molecular layer interneurons (MLIs) to suppress Purkinje cell firing in the mouse cerebellar vermis.

Aug 18, 2023 | cell.com | Nanyang Technological |George J. Augustine

Highlights • Synapsins cluster synaptic vesicles by liquid-liquid phase separation and by tetramerization • Synapsin-dependent liquid-liquid phase separation clusters vesicles at GABAergic synapses • Synapsin tetramerization cross-links vesicles at glutamatergic synapses • These synapsin-dependent processes confer different properties on GABA and glutamate release Summary Synapsins cluster synaptic vesicles (SVs) to provide a reserve pool (RP) of SVs that maintains synaptic transmission...