Georgia Menounou

Mar 18, 2024 | onlinelibrary.wiley.com | Kane McQuaid |Joseph Hennessy |Georgia Menounou |Alex Gibney

DNA binding by intercalation , showing both sequence and enantiospecificity, of a ruthenium diimine complex, is reported by Christine Cardin, Andrew Kellett et al. in their Research Article (e202318863). The right-handed helix seen in the crystal structure shows variable degrees of twisting, including the first intercalation by a ruthenium complex from the DNA major groove. In solution, the lambda enantiomer was found to be more stabilising with a range of DNA sequences.

Jan 25, 2024 | onlinelibrary.wiley.com | Kane McQuaid |Joseph Hennessy |Georgia Menounou |Alex Gibney

Introduction The DNA decamer sequence d(CCGGTACCGG) is remarkable in spontaneously crystallising in the X-stacked Holliday junction form.1 The original serendipitous discovery was made while crystallising mismatched decamers, and the crystallised assembly had the structure predicted from solution studies.2 A systematic study of all 64 self-complementary combinations of d(CCN1N2N3n3n2n1GG) then showed that the presence of ACC as the central triplet gave only the junction form under the...