Ghulam Rehman Mohyuddin

Oct 15, 2024 | nature.com | Ghulam Rehman Mohyuddin |Rajshekhar Chakraborty |Samer Al Hadidi

Dear Editor,Humans rely on heuristics to simplify decision-making [1] and often use chronological age as a key factor. However, chronological age may not accurately reflect an individual’s physiological age and functional performance [2]. A notable heuristic in decision-making is left-digit bias, where humans tend to categorize decisions based on the left-most digit of a continuous variable (e.g., age, blood pressure) [3].

Aug 11, 2024 | nature.com | Rajshekhar Chakraborty |Aniko Szabo |Carolina Schinke |Binod Dhakal |Ghulam Rehman Mohyuddin |Martin Kaiser | +1 more

To the Editor:Bispecific antibodies [bsAb] targeting B-cell maturation antigen [BCMA] and G-protein-coupled receptor class C group 5 member D [GPRC5D] have demonstrated deep and durable responses in patients with relapsed/refractory multiple myeloma [MM], with single-agent response rates from 57–71% [1,2,3,4,5,6].

Apr 22, 2024 | nature.com | Ghulam Rehman Mohyuddin

Certain subsets of patients with multiple myeloma or its precursor conditions are overtreated with current approaches to therapy. Herein, we highlight several key areas where we believe de-escalation of treatment is needed. Dedicated trials to assess these de-escalation approaches and urgent changes to current clinical practices are needed.