Gina Mayer

1 month ago | cell.com | Ben Zhao |Rui Fang |Gina Mayer |Marija Trajkovic-Arsic |Kristina Althoff |Jiajin Yang | +10 more

Keywords PDAC MEK trametinib PLK1 volasertib synergism G2/M checkpoint cell cycle JNK KRAS G1 arrest cJUN MAPK therapy resistance PDO organoids Research topic(s) CP: Cancer Introduction Pancreatic ductal adenocarcinoma (PDAC) stands as one of the most lethal malignancies and ranks as the fourth leading cause of cancer-related deaths worldwide.1 Despite significant strides in comprehending the disease’s pathobiology and the introduction of precision oncology approaches, patient mortality rates...