Giorgio Minotti

Jul 1, 2024 | jacc.org | Massimiliano Camilli |Carlo Maria Cipolla |Susan Dent |Giorgio Minotti

Introduction Since the 1980s, anthracyclines, including doxorubicin, daunorubicin, epirubicin, and idarubicin, have been central to treating various hematologic and solid malignancies, such as Hodgkin lymphoma (HL), non-Hodgkin lymphoma (nHL), acute leukemias, breast cancer (BC), ovarian cancer, and sarcomas.1,2 In clinical practice, the application of anthracyclines is limited by a dose-dependent cardiotoxicity, leading to both systolic and diastolic cardiac dysfunction and, in less common...

Oct 9, 2023 | jpet.aspetjournals.org | Giorgio Minotti |Massimiliano Camilli

High plasma levels of low-density lipoprotein cholesterol (LDL-C) have long been known to associate with a measurable increase of cardiovascular (CV) events in the general population. LDL-C lowering drugs, from the venerable statins to ezetimibe and PCSK9 inhibitors, are therefore pillars of the clinical management of patients with high LDL-C, but the magnitude of reduction of CV events in the at-risk patients remains a matter of controversy.

Jul 18, 2023 | pubmed.ncbi.nlm.nih.gov | Giorgio Minotti

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Jul 17, 2023 | jpet.aspetjournals.org | Giorgio Minotti

EditorialSpecial Section on Clinical Pharmacology—Editorial A Special Section on Clinical Pharmacology—Editorial Journal of Pharmacology and Experimental Therapeutics August 2023, 386 (2) 115-116; DOI: https://doi.org/10.1124/jpet.123.001743

Feb 24, 2023 | jpet.aspetjournals.org | Giorgio Minotti

The March issue of the Journal of Pharmacology and Experimental Therapeutics offers an interesting read on palonosetron for managing nausea and vomiting in beagle dogs treated with the anticancer agent cisplatin (Levijoki et al., 2023). The subject matter is anything but novel.