Giovanni D’Arena

Aug 14, 2024 | nature.com | Erika Tissino |Federico Pozzo |Francesca Rossi |Riccardo Bomben |Riccardo Moia |Giovanni D’Arena | +4 more

AbstractIn chronic lymphocytic leukemia (CLL), survival of neoplastic cells depends on microenvironmental signals at lymphoid sites where the crosstalk between the integrin VLA-4 (CD49d/CD29), expressed in ~40% of CLL, and the B-cell receptor (BCR) occurs. Here, BCR engagement inside–out activates VLA-4, thus enhancing VLA-4-mediated adhesion of CLL cells, which in turn obtain pro-survival signals from the surrounding microenvironment.