Gisella Vetere

Aug 1, 2023 | frontiersin.org | Szu-Han Wang |Gisella Vetere |Gareth Barker

1. Introduction The nucleus reuniens of the thalamus (RE) is ideally situated to mediate information exchange between the hippocampus and prefrontal cortex (PFC) and participate in a variety of higher cognitive functions (reviews: Dolleman-van der Weel et al., 2019; Mathiasen et al., 2020; Ferraris et al., 2021). One of the most interesting lines of research suggests that RE is critical for long-term memory consolidation (Ferraris et al., 2021).

Apr 6, 2023 | nature.com | Gisella Vetere

Stegemann et al. have unraveled a long-lasting role for fear engrams in future pain perception. Prefrontal pain and fear representations become entangled following a fearful event. As subsequent painful experiences also reactivate the fear network, silencing the fear engram alone can alleviate both tonic pain and hypersensitivity in chronic pain.