Giulio Caravagna

Aug 7, 2024 | nature.com | Alex J. Cornish |Andreas Gruber |Ben Kinnersley |Anna Frangou |Giulio Caravagna |Boris Noyvert | +23 more

AbstractColorectal carcinoma (CRC) is a common cause of mortality1, but a comprehensive description of its genomic landscape is lacking2,3,4,5,6,7,8,9. Here we perform whole-genome sequencing of 2,023 CRC samples from participants in the UK 100,000 Genomes Project, thereby providing a highly detailed somatic mutational landscape of this cancer.

Mar 27, 2023 | nature.com | Giulio Caravagna

A new study deciphers the origin and evolution of childhood neuroblastoma using genome sequencing data, mathematical models and statistical inference, showing how neuroblastoma evolution is an accurate predictor of outcome. In 1976, Peter Nowell1 proposed the clonal evolution model as a basic framework for understanding how cancers evolve over time.