Giuseppe Gangarossa

Jun 28, 2024 | cell.com | Fiona Henderson |Giuseppe Gangarossa

Highlights•VGLUT3 expression identifies subsets of 5-HT and non-5-HT DR neurons activated by acute stress•Selective activation of VGLUT3-expressing neurons in the DR modulates wake and REMS•Reduced VGLUT3 expression in the DR attenuates stress-induced sleep perturbations•VGLUT3 expression in 5-HT neurons exerts minimal influence on sleepSummaryExposure to stressors has profound effects on sleep that have been linked to serotonin (5-HT) neurons of the dorsal raphe nucleus (DR).