Giuseppe Insana

Mar 6, 2024 | biorxiv.org | Giuseppe Insana |Maria Martin |María Martín |William Pearson

AbstractThe "canonical" protein sets distributed by UniProt are widely used for similarity searching, and functional and structural annotation. For many investigators, canonical sequences are the only version of a protein examined. However, higher eukaryotes often encode multiple isoforms of a protein from a single gene. For unreviewed (UniProtKB/TrEMBL) protein sequences, the longest sequence in a Gene-Centric group is chosen as canonical.