Giuseppina Mariano

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Structure and rational engineering of the PglX methyltransferase and specificity factor for BREX phage defence - Nature Communications

Aug 21, 2024 | nature.com | Sam Went |Aisling Brady |Giuseppina Mariano |Darren Smith

AbstractBacteria have evolved a broad range of systems that provide defence against their viral predators, bacteriophages. Bacteriophage Exclusion (BREX) systems recognise and methylate 6 bp non-palindromic motifs within the host genome, and prevent replication of non-methylated phage DNA that encodes these same motifs. How BREX recognises cognate motifs has not been fully understood.

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