Glenn M. Toney

Feb 14, 2024 | jneurosci.org | Mary Andrade |Tamara T. Truong |Glenn M. Toney

Glutamate Spillover Dynamically Strengthens Gabaergic Synaptic Inhibition of the Hypothalamic Paraventricular Nucleus Junya Yamaguchi, Mary Ann Andrade, Tamara T. Truong, Glenn M. Toney Journal of Neuroscience 14 February 2024, 44 (7) e1851222023; DOI: 10.1523/JNEUROSCI.1851-22.2023

Dec 21, 2023 | jneurosci.org | Mary Andrade |Glenn M. Toney |Tamara T. Truong

AbstractThe hypothalamic paraventricular nucleus (PVN) is strongly inhibited by γ-aminobutyric acid (GABA) from the surrounding peri-nuclear zone (PNZ). Because glutamate mediates fast excitatory transmission and is substrate for GABA synthesis, we tested its capacity to dynamically strengthen GABA inhibition.