Gnimah Eva Gnouamozi

May 14, 2024 | cell.com | Zhi Xu |Sina Rüeger |Patrick Shea |Gnimah Eva Gnouamozi

SummaryEvolutionary changes in the hepatitis B virus (HBV) genome could reflect its adaptation to host-induced selective pressure. Leveraging paired human exome and ultra-deep HBV genome-sequencing data from 567 affected individuals with chronic hepatitis B, we comprehensively searched for the signatures of this evolutionary process by conducting “genome-to-genome” association tests between all human genetic variants and viral mutations.