Gordon Guyatt

1 month ago | bmj.com | Gordon Guyatt |Alfonso Iorio |Hans de Beer |Andrew Owen |Thomas Agoritsas |M Hassan Murad | +11 more

Research Methods & Reporting Core GRADE: Indirectness BMJ 2025; 389 doi: https://doi.org/10.1136/bmj-2024-083865 Cite this as: BMJ 2025;389:e083865 Gordon Guyatt, distinguished professor1 2 3, Alfonso Iorio, professor1 2, Hans De Beer, methodologist4, Andrew Owen, professor5, Thomas Agoritsas, professor1 3 6, M Hassan Murad, professor7, Ganesan Karthikeyan, professor, executive director8 9, Carlos Cuello, assistant professor1, Manya Prasad, associate professor10, Kevin Kim, methodologist1 11,...

Aug 24, 2024 | thelancet.com | Ya Gao |Gordon Guyatt |Timothy M. Uyeki |Ming Liu

Research in contextEvidence before this studyAntivirals are frequently used in the clinical management of people with severe influenza. Previous systematic reviews and meta-analyses have reported that early initiation of neuraminidase inhibitor treatment in hospitalised patients with influenza might be associated with reduced mortality and length of hospital stay compared with later or no neuraminidase inhibitor treatment.

Apr 3, 2024 | jclinepi.com | Martin Mayer |East Carolina |Gordon Guyatt |Richard Riley

This paper is only available as a PDF. To read, Please Download here. AbstractPrognostic models incorporate multiple prognostic factors to estimate the likelihood of future events for individual patients based on their prognostic factor values. Evaluating these models crucially involves conducting studies to assess their predictive performance, like discrimination. Systematic reviews and meta-analyses of these evaluation studies play an essential role in selecting models for clinical practice.

Mar 28, 2024 | jamanetwork.com | Stefan Schandelmaier |Gordon Guyatt

Sherry et al1 considered the methodological quality of subgroup analyses reported in 379 oncology trials. The authors explored a number of fundamental problems with these analyses: in forest plots, use of linear rather than logarithmic scales and failure to present overall pooled estimates; failure to conduct and highlight tests of interaction; and readiness to make unwarranted inferences regarding the credibility of postulated subgroup effects.

Sep 20, 2023 | jclinepi.com | M. Hassan Murad |Mohammed T Ansari |David Rind |Gordon Guyatt

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