Gordon Guyatt

Aug 24, 2024 | thelancet.com | Ya Gao |Gordon Guyatt |Timothy M. Uyeki |Ming Liu

Research in contextEvidence before this studyAntivirals are frequently used in the clinical management of people with severe influenza. Previous systematic reviews and meta-analyses have reported that early initiation of neuraminidase inhibitor treatment in hospitalised patients with influenza might be associated with reduced mortality and length of hospital stay compared with later or no neuraminidase inhibitor treatment.

Apr 3, 2024 | jclinepi.com | Martin Mayer |East Carolina |Gordon Guyatt |Richard Riley

This paper is only available as a PDF. To read, Please Download here. AbstractPrognostic models incorporate multiple prognostic factors to estimate the likelihood of future events for individual patients based on their prognostic factor values. Evaluating these models crucially involves conducting studies to assess their predictive performance, like discrimination. Systematic reviews and meta-analyses of these evaluation studies play an essential role in selecting models for clinical practice.

Mar 28, 2024 | jamanetwork.com | Stefan Schandelmaier |Gordon Guyatt

Sherry et al1 considered the methodological quality of subgroup analyses reported in 379 oncology trials. The authors explored a number of fundamental problems with these analyses: in forest plots, use of linear rather than logarithmic scales and failure to present overall pooled estimates; failure to conduct and highlight tests of interaction; and readiness to make unwarranted inferences regarding the credibility of postulated subgroup effects.

Sep 20, 2023 | jclinepi.com | M. Hassan Murad |Mohammed T Ansari |David Rind |Gordon Guyatt

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Jun 22, 2023 | thelancet.com | Gordon Guyatt

SummaryThe optimal isolation duration for patients with COVID-19 remains unclear. To support an update of World Health Organization (WHO)'s Living Clinical management guidelines for COVID-19 (https://www.who.int/publications/i/item/WHO-2019-nCoV-clinical-2022.2), this rapid systematic review and modelling study addresses the effects of different isolation periods for preventing onward transmission leading to hospitalisation and death among secondary cases.