Grant A. Pellowe

Jun 21, 2024 | cell.com | Sarah Maslen |Grant A. Pellowe |Steven Howell |Joanna Redmond

Highlights•Trigger factor binds collapsed folding intermediates and outcompetes DnaJ•DnaJ recruits DnaK to both partially and extensively folded intermediates•Chaperone binding is disfavored close to the ribosome surface•Chaperone binding does not reverse cotranslational foldingSummaryProtein folding is assisted by molecular chaperones that bind nascent polypeptides during mRNA translation.