Grant Stewart

Jan 16, 2025 | nature.com | Sabrina Rossi |Laura Godfrey |Justicia Kyeremeh |Thomas Mitchell |Grant Stewart |Roland F. Schwarz

AbstractClear cell renal cell carcinoma (ccRCC) is characterised by significant genetic heterogeneity, which has diagnostic and prognostic implications. Very limited evidence is available regarding DNA methylation heterogeneity. We therefore generate sequence level DNA methylation data on 136 multi-region tumour and normal kidney tissue from 18 ccRCC patients, along with matched whole exome sequencing (85 samples) and gene expression (47 samples) data on a subset of samples.