Gregory A Fishbein

Featured in: Favicon

nature.com Favicon

aacrjournals.org Favicon

biorxiv.org Favicon

cardiovascularpathology.com Favicon

onlinelibrary.wiley.com Favicon

ard.bmj.com Favicon

cancerres.aacrjournals.org

Articles

RV-specific Targeting of Snai1 Rescues Pulmonary Hypertension-induced Right Ventricular Failure by Inhibiting EndMT and Fibrosis via LOXL2 Mediated Mechanism

May 3, 2024 | biorxiv.org | Somanshu Banerjee |Jason Hong |Sandra Martineau |Gregory A Fishbein

AbstractBackground: Pulmonary hypertension (PH)-induced right ventricular (RV) failure (PH-RVF) is a significant prognostic determinant of mortality and is characterized by RV hypertrophy, endothelial-to-mesenchymal transition (EndMT), fibroblast-to-myofibroblast transition (FMT), fibrosis, and extracellular matrix (ECM)-remodeling. Despite the importance of RV function in PH, the mechanistic details of PH-RVF, especially the regulatory control of RV EndMT, FMT, and fibrosis, remain unclear.

Contact details

Emails

[email protected]

Socials & Sites

Try JournoFinder For Free

Search and contact over 1M+ journalist profiles, browse 100M+ articles, and unlock powerful PR tools.

Start Your 7-Day Free Trial →