Guangjun Nie

Dec 20, 2024 | cell.com | Yang Chen |Hao Qin |Nan Li |Yaohua Wei |Yixuan Lin |Ronghui Deng | +10 more

Keywords autologous tumor vaccines tumor membrane antigens neoadjuvant chemotherapy liposomal doxorubicin Introduction Surgery continues to be the primary treatment modality for the majority of solid tumors; however, the challenges of postoperative tumor recurrence and metastasis persist.1,2 Various strategies have been devised in response to these challenges, including using autologous tumor vaccine.3,4,5 These personalized vaccines leverage patients’ tumor cells as a source of antigens to...

Jun 7, 2024 | nature.com | Junchao Xu |Guangjun Nie

Correction to: Signal Transduction and Targeted Therapy https://doi.org/10.1038/s41392-024-01794-4, published online 15 April 2024After the article was published online,1 the authors noticed one inadvertent mistake in Supplementary Fig. S19. The image of lung H&E in the Lip-Dox group was repeatedly inserted as the image of Dox group by mistake during the preparation of the figures. The correct figure was provided as follows.

Apr 14, 2024 | nature.com | Junchao Xu |Guangjun Nie

AbstractThe inadequate tumor accumulation of anti-cancer agents is a major shortcoming of current therapeutic drugs and remains an even more significant concern in the clinical prospects for nanomedicines. Various strategies aiming at regulating the intratumoral permeability of therapeutic drugs have been explored in preclinical studies, with a primary focus on vascular regulation and stromal reduction. However, these methods may trigger or facilitate tumor metastasis as a tradeoff.

Aug 14, 2023 | nature.com | Yuliang Zhao |Guangjun Nie

AbstractConformational cooperativity is a universal molecular effect mechanism and plays a critical role in signaling pathways. However, it remains a challenge to develop artificial molecular networks regulated by conformational cooperativity, due to the difficulties in programming and controlling multiple structural interactions.