Guangming Wang

Apr 25, 2024 | nature.com | Guangming Wang |Bing Lu |Jun Xu

AbstractThe long-term maintenance of leukaemia stem cells (LSCs) is responsible for the high degree of malignancy in MLL (mixed-lineage leukaemia) rearranged acute myeloid leukaemia (AML). The DNA damage response (DDR) and DOT1L/H3K79me pathways are required to maintain LSCs in MLLr-AML, but little is known about their interplay. This study revealed that the DDR enzyme ATM regulates the maintenance of LSCs in MLLr-AML with a sequential protein-posttranslational-modification manner via CBP-DOT1L.

Aug 26, 2023 | pubs.rsc.org | Rong Fu |Guangming Wang |Qingyun Zhan |Lili Zhang

Defect ZrO2-x supported Ru nanoparticles as Mott-Schottky photocatalyst for efficient ammonia synthesis at ambient conditions Well-crafted semiconductors exhibiting favorable band structures and strong electron-donating properties can provide a viable pathway for solar-driven nitrogen activation under ambient conditions. In this study, we demonstrate that the nitrogen photo-fixation process can be enhanced by introducing oxygen vacancies and Ru co-catalyst.