Guangwen Chen

Jan 9, 2025 | sciencedirect.com | Wenbo Han |Hongpeng Zhang |Qiang Zhang |Guangwen Chen

mRNA-based therapies, regarded as groundbreaking technologies, offer great potential for revolutionizing infectious disease prevention and cancer treatment. However, the large size and negative charge of mRNA molecules impede their cellular uptake, and their susceptibility to RNase degradation in biological fluids compromises their stability [1].