Guillermo Najarro

Oct 29, 2024 | journals.plos.org | Guillermo Najarro |Kevin Brackett |Hunter Woosley |PLOS Pathogens

Loading metrics Open Access Peer-reviewedResearch Article ? This is an uncorrected proof. Citation: Najarro G, Brackett K, Woosley H, Dorman LC, Turon-Lagot V, Khadka S, et al. (2024) BiP/GRP78 is a pro-viral factor for diverse dsDNA viruses that promotes the survival and proliferation of cells upon KSHV infection. PLoS Pathog 20(10): e1012660. https://doi.org/10.1371/journal.ppat.1012660Editor: Laurie T.

Sep 30, 2023 | biorxiv.org | Kevin Brackett |Guillermo Najarro |Hunter Woosley |Catya Faeldonea

AbstractThe Endoplasmic Reticulum (ER)-resident HSP70 chaperone BiP (HSPA5) plays a crucial role in maintaining and restoring protein folding homeostasis in the ER. BiP function is often dysregulated in cancer and virus-infected cells, conferring pro-oncogenic and pro-viral advantages. We explored BiP functions during infection by the Kaposi's sarcoma-associated herpesvirus (KSHV), an oncogenic gamma-herpesvirus associated with cancers of immunocompromised patients.