Guo Rui

Dec 28, 2023 | zgsydw.cnjournals.com | Báo Nhân Dân |Guo Rui |HOU Daorong

摘要: 目的 探究角蛋白17(keratin 17,Krt17)基因敲除对糖尿病小鼠创面愈合的影响。 方法 取6 周龄野生型小鼠和Krt17 基因敲除小鼠,利用60%高脂饲料喂养4 周和腹腔注射链脲佐菌素(40 mg/ (kg·d),连续5 d)联合诱导建立糖尿病小鼠模型;于造模成功后1 周,小鼠异氟烷全身麻醉,背部剃毛,用6 mm 环钻制造在体的皮肤圆形损伤;于制造创面后第8 天,利用Western blot 和免疫荧光染色检测KRT17 在创面近端中的表达和定位及病理组织学分析;并于制造创面后第0、2、4、6和8天拍照记录,计算伤口愈合速率。 结果 在正常生理情况下,KRT17 主要在小鼠毛囊中表达;当皮肤受到损伤时,创面近端的角质形成细胞中KRT17 的表达显著升高;而糖尿病小鼠创面中KRT17 的表达较对照组小鼠显著下调。与野生型小鼠相比,Krt17 基因敲除小鼠的伤口愈合速率显著降低;创面局部炎症反应更持续。 结论 Krt基因敲除加剧了糖尿病小鼠的创面愈合障碍,Krt可能是参与该病理进程的重要调控基因之一。

Dec 15, 2023 | mdpi.com | Guo Rui |Zhang-Yi Qin |Ya-Qing Chang |Yu-Guang Zheng

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Sep 22, 2023 | chinatrfl.alljournal.net.cn | Guo Rui |Jin guang |Zhou Ping |ZHOU Gen-hua

In order to understand the nutrient status of soil and the contamination of heavy metals and antibiotics in major peach orchards in Fujian province，this study determined the nutrient contents of organic fertilizer and soil，heavy metal residues in soil samples，and the antibiotic contents of organic fertilizer and soil in six peach orchards in Gutian county of Ningde city，Liancheng county of Longyan city，Jianyang district and Jianou county of Nanping city，Jin’an district and Minhou county of...

Jan 2, 2023 | scmp.com | Guo Rui |Jun Mai |William Zheng

Dec 25, 2022 | scmp.com | Guo Rui