Guoqing Xiang

Aug 10, 2023 | nature.com | Guoqing Xiang |Hung Nguyen Do |Joshua Levitz |Yinglong Miao

Abstractα1-adrenergic receptors (α1-ARs) play critical roles in the cardiovascular and nervous systems where they regulate blood pressure, cognition, and metabolism. However, the lack of specific agonists for all α1 subtypes has limited our understanding of the physiological roles of different α1-AR subtypes, and led to the stagnancy in agonist-based drug development for these receptors.