Guorong Li

4 weeks ago | biorxiv.org | Jessica Chan |A Thomas Read |Guorong Li |Lin Cheng

AbstractTrabecular meshwork (TM) cell therapy has been proposed as a next-generation treatment for elevated intraocular pressure (IOP) in glaucoma, the most common cause of irreversible blindness. Using a magnetic cell steering technique with excellent efficiency and tissue-specific targeting, we delivered two types of cells into a mouse model of glaucoma: either human adipose-derived mesenchymal stem cells (hAMSCs) or induced pluripotent cell derivatives (iPSC-TM cells).

Apr 2, 2024 | onlinelibrary.wiley.com | Guorong Li |Joseph van Batenburg-Sherwood |Babak N. Safa |Andrea Wilson

AHD aqueous humor dynamics C outflow facility CC collector channels CI confidence interval DAPI 4′,6-diamidino-2-phenylindole DBG Dulbecco's phosphate-buffered saline with added D-glucose IOP intraocular pressure JCT juxtacanalicular tissue OCT optical coherence tomography P pressure PBS phosphate-buffered saline Q flow rate SC Schlemm's canal SD spectral domain TM trabecular meshwork β nonlinearity factor 1 INTRODUCTION Age and elevated intraocular pressure (IOP) are the two primary risk...