Guozhen Liu

Dec 15, 2024 | mdpi.com | Guozhen Liu

1. IntroductionNucleic acids are a type of biopolymer which is a fundamental component for storing, encoding, transmitting, and expressing genetic information in living organisms. Due to the unique nucleic acid sequences in each species, nucleic acids have become a crucial factor in classifying biological populations [1,2].

Dec 1, 2024 | mdpi.com | Weixin Liu |Hao Zhang |Guozhen Liu |Xinyu Yin

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May 30, 2024 | pubs.rsc.org | Ya Zhang |Yue Guo |Guozhen Liu |Shiqi Zhou

Portable all-in-one microfluidic system for CRISPR–Cas13a-based fully integrated multiplexed nucleic acid detection† Point-of-care testing of “sample in, answer out” is urgently needed for communicable diseases. Recently, rapid nucleic acid tests for infectious diseases have been developed for use in resource-limited areas, but they require types of equipment in central laboratories and are poorly integrated.

Sep 14, 2023 | frontiersin.org | Facultad de Ciencias |Guozhen Liu

Initially, biosensors were considered to be any analytical probe that provided a quantifiable signal in a biological medium, such as pH and oxygen electrodes. Today, we define them as analytical devices that can determine the presence of biological elements or biomolecules in a sample and are capable of converting a physical or chemical signal into an optically or electrically measurable signal. In 1962, Clark and Lyons developed the first electrochemical biosensor to measure glucose.

Jul 7, 2023 | frontiersin.org | Guozhen Liu

Gallium-based liquid metals have presented fascinating properties including high electrical conductivity, excellent fluidity at room temperature, favorable biocompatibility and intriguing interfacial characteristics, which are especially suitable for flexible electronics and interfaces. Recently liquid metal-based electronics and devices have been used for biomedical applications such as bioelectronic systems and biomedical sensing for physiological signal monitoring.