Guy Pratt

Sep 7, 2024 | nature.com | Sian E. Faustini |Alec Rapson |Guy Pratt |Mark T Drayson

To the Editor:Multiple myeloma (MM) is a cancer of plasma cells in the bone marrow associated with profound immunosuppression and high infection-related morbidity and mortality. In the first three months following diagnosis, serious bacterial infections affect a third of patients and infection contributes to half of all early mortality [1, 2].

Jan 24, 2024 | nature.com | Guy Pratt |Jianmin Zuo |Paul Moss

Cancer patients who are immune suppressed remain at increased risk from COVID-19 and have recently been prioritised for additional booster bivalent vaccines. Despite this, previous studies have shown that humoral and cellular immune responses often fail to reach levels comparable to the general population following booster doses.

Jun 14, 2023 | mdpi.com | Guy Pratt |Hannah Giles |Jennifer Pinney

Abstract:Renal disorders are uncommonly associated with IgM MGUS and Waldenström macroglobulinaemia (WM). Data are limited to large case series that suggest that related renal involvement occurs in 5% of patients with WM. Although uncommon, there is a much greater variety of renal pathologies associated with WM and IgM MGUS than that seen in patients with multiple myeloma, where cast nephropathy predominates.