Hadi Rahmaninejad

Oct 12, 2024 | biorxiv.org | Hadi Rahmaninejad |Yao Xiao |Maxime M.C. Tortora |Geoffrey Fudenberg

AbstractIn mammalian interphase cells, genomes are folded by cohesin loop extrusion limited by directional CTCF barriers. This interplay leads to the enrichment of cohesin at barriers, isolation between neighboring topologically associating domains, and elevated contact frequency between convergent CTCF barriers across the genome.