Hailee N. Nerber

Jun 22, 2024 | onlinelibrary.wiley.com | Diogo Martins |Hailee N. Nerber |Charlotte G. Roughton |Amaury Fasquelle

1 INTRODUCTION Clostridioides difficile is an obligate anaerobic intestinal pathogen (Abt et al., 2016; Smits et al., 2016). It has the ability to differentiate into endospores (referred to as spores), and it uses these oxygen-resistant cells for environmental persistence and transmission (Deakin et al., 2012; Smits et al., 2014). Spores consist of a central compartment, the core, which holds the genome and is delimited by the spore's inner membrane.