Hairong Huang

Sep 7, 2024 | scienceopen.com | Shuqi Wang |Qing Sun |Guanglu Jiang |Hairong Huang

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), was the second leading infectious cause of death after COVID-19 in 2022, and is a major contributor to antimicrobial resistance worldwide [1]. Pyrazinamide (PZA), a first-line drug for TB treatment, is effective in killing Mtb. Inclusion of PZA in treatment regimens for drug-susceptible patients significantly shortens therapy duration, from 12 to 6 months [2].