Hannah Ferris

2 weeks ago | science.org | Hannah Ferris |Scott Earley |Leslie K. Ferrarelli |Danielle Jeffrey

Editor’s summaryIncreased intraluminal pressure in the brain elicits the constriction of arterioles, which is usually mediated by smooth muscle cells situated in arteriole walls. However, Ferris et al. found that, in the mouse brain, this role was extended to mural cells called pericytes that reside on the transitional blood vessel segments between arterioles and capillaries (see also the Focus by Earley).

2 weeks ago | science.org | Hannah Ferris |Scott Earley |Leslie K. Ferrarelli

AbstractThe innate immunity mediator STING senses and repairs lysosomal dysfunction. SIGN UP FOR THE AWARD-WINNING SCIENCEADVISER NEWSLETTER The latest news, commentary, and research, free to your inbox daily Inflammation in the brain contributes to the pathology and progression of various neurological and neurodegenerative diseases. The innate immunity mediator STING is implicated in driving this inflammation (see Wang et al. in the Science Signaling Archive). However, Tang et al.

2 weeks ago | science.org | Hannah Ferris |Scott Earley |Leslie K. Ferrarelli

AbstractIntrinsic control of cerebral blood flow in response to intravascular pressure is traditionally attributed to smooth muscle cells in arterioles. However, in this issue of Science Signaling, Ferris et al. demonstrate that capillary constriction is caused by pressure-induced depolarization of pericytes, mural cells that encircle capillaries, and is mediated by TRPC3 cation channels, identifying the channel as critical for fine-tuning brain perfusion.