Hannah Han

Mar 18, 2024 | nature.com | Danny D. Sahtoe |Ewa Andrzejewska |Hannah Han |Matthias Schneider |Georg Meisl |Hannah Nguyen | +2 more

AbstractSegments of proteins with high β-strand propensity can self-associate to form amyloid fibrils implicated in many diseases. We describe a general approach to bind such segments in β-strand and β-hairpin conformations using de novo designed scaffolds that contain deep peptide-binding clefts. The designs bind their cognate peptides in vitro with nanomolar affinities.

Feb 28, 2023 | yaledailynews.com | Hannah Han

New York Times Eric Li (YSM ’25) and his three lab partners stared at the coffin-sized metal box. The steel glinted beneath the lights, austere and impenetrable. Through his mask, Li inhaled the faint, familiar smell of formaldehyde. Only moments before, one hundred of Li’s fellow first-year Yale medical students had filed into the cavernous, glass-paneled laboratory on the third floor of The Anlyan Center for Medical Research and Education, a block away from the Yale School of Medicine.