Hannah K. Neikes

3 weeks ago | cell.com | Nguyen NGUYEN |NGuyen nguyen |Sira Gevers |Rutger Kok |Lotte M. Burgering |Hannah K. Neikes | +11 more

Keywords cancer metabolism stem cells cell types cell plasticity differentiation organoids live imaging single-cell tracking heterogeneity cell-cell interactions Introduction Epithelial tissue maintenance relies on self-renewing stem cells, with mutations in stemness-regulating pathways causing uncontrolled cell proliferation and tumor formation.1 In the intestine, WNT activity is the main regulator of the stem cell state, and its overactivation drives tumorigenesis.2,3,4 Despite a general...