Haosen Zhang

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Effect of PVP and HPMC on production of indomethacin amorphous nanoparticles: experiments and molecular dynamics simulations

3 weeks ago | tandfonline.com | Wenhui Zhou |Mengmeng Han |Haosen Zhang |Tianwei Zhang

AbstractObjectiveThis study investigated the effect of molecular interactions between drug and polymers on preparation of nanoamorphous indomethacin through milling of solid dispersions. SignificanceThe polymer selection (molecular interaction) emerged as a critical factor in the dynamic milling process for achieving nanoamorphous drug. MethodsPolyvinylpyrrolidone (PVP) and hydroxypropyl methylcellulose (HPMC) were selected as models.

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