Hardcastle AJ

Dec 2, 2024 | bjo.bmj.com | Samantha Lee |Fiona Stapleton |Stuart Macgregor |Hardcastle AJ

IntroductionA layperson may usually imagine a single gene determining one’s predisposition to a disease. However, single-gene conditions make up only a small proportion of known human disorders. The majority of human diseases are considerably more complex, each caused by the collective effects of many genetic variants and are often complicated by the contribution of environmental factors to these traits.